M11

• Mechanism of action of mebendazole

  • Inhibiting microtubule synthesis in helminthes and irreversible impairment of glucose uptake
• the patient has giardiasis. The doctor prescribed metronidazole. What is the most common side effect of metronidazole

  • Diarrhea
• A drug used to kill flukes

  • Praziquantel
• Thiabendazole is rarely used now because

  • It frequently produces incapacitating side effects
• Dr. Trixie request your help in prescribing a protease inhibitor for his patient. She has heard that not all agents are the same and asks for your recommendation as to which agent would penetrate the blood-brain barrier.

  • Ritonavir
• Antiviral agents that are active against cytomegalovirus (CMV)

  • Ganciclovir
• Inhibits microtubule synthesis by decreasing glucose uptake

  DOC: Echinococcus

  • Albendazole
• Inhibits microtubules synthesis and depletes glucose inducing paralysis of the worm

  DOC: Ascaris, Pinworm, Whipworm

  • Mebendazole (Antiox)
• Depolarizing neuromuscular agent (nicotinic receptors) causing spastic paralysis of the worm

  TARGETS: Ascaris, Hookworm, and enterobius infestation

  • Pyrantel Pamaote
• Increase membrane permeability to calcium contraction vacuolization parasite death

  • Praziquantel
• Inhibits oxidative phosphorylation in mitochondria of cestodes

  • Niclosamide
• Entry of HIV into cell can also be blocked by fusion inhibitor, such as Enfuvirtide
• No longer recommended as prophylaxis or treatment for influenza A viruses

  • Amantadine
  • Rimantadine
• Used for treating herpes infections, especially genital herpes

  • Acyclovir
• A nucleotide analog, has been introduced for patients whose hepatitis B infections are resistant to Lamivudine

  • Adefovir Dipivoxil
• Another nucleoside analog which is currently used to treat cytomegalovirus infection of the eye

  • Cidofovir
• NRTI (Nucleoside Reverse Transcriptase Inhibitors)
• Recommended for the management of adult patients w/ symptomatic HIV infection who have history of confirmed Pneumocystis carinii pneumonia

  • Ziduvodine
• Drug for Herpes and Varicella

  Systemic treatment

  • Acyclovir
  • Valacyclovir
  • Famciclovir
  • Penciclovir
  • Docosanol
• Anti-Influenza agents

  • Amantadine
  • Rimantadine
  • Oseltamivir
  • Zanamivir
• Drug Cytomegalovirus (CMV)

  • Ganciclovir
  • Valganciclovir