To apoptose

• Shrink and develop bubble-like blebs on their surface, chromatin DNA and protein) in their nucleus degrades and mitochondria break down
• Whole cell breaks down into small membrane-wrapped, apoptotic vesicles, releases ATP binding to receptors on phagocytic cell like macrophages and attract them to dying cells (”find-me” signal)
• Phospholipid phosphatidylserine, which is normally hidden in plasma membrane is exposed on surface as an “eat me” signal to phagocytes which then engulf cell fragments and secrete cytokines that inhibit inflammation