Organisms react to changes in any of the above environmental conditions. Any coordinated response requires a stimulus, a receptor and an effector. In humans, the nervous system controls our response to external changes. It is made up of two parts; the central nervous system, which includes the brain and spinal cord, and the peripheral nervous system which contains receptors connected to nerves or neurons and effectors, also connected to neurons. Receptors are the first to respond to stimuli and are found in our sense organs. They are connected to the central nervous system via peripheral neurons. Effectors are mainly muscles and organs that secrete hormones - called glands; these are also connected to the central nervous system via neurons