The side effects of ifosfamide include hemorrhagic cystitis, leukopenia, neurotoxicity Fanconi syndrome, N&V, alopecia, hepatic enzyme elevations.
Symptoms of leukopenia is WBC nadir, occurs between day 8 to 13; recovery usually be completed by day 17-18 of treatment cycle.
Symptoms of neurotoxicity include encephalopathy (cerebellar ataxia - inability to coordinate muscle movement, mental confusion, complex visual hallucinations)
Treatment of neurotoxicity is methylene blue / methylthioninium chloride.