Article

• What mechanism do bacterias use in aquired resistance?

  DNA mutation

  DNA transfer - free DNA, bacteriophage, plasmids
• What is the main target of collistin on acinetobacter baumannii?

  The LPS layer
• How does A. Beaumannii get resistant to collistin?

  1. Modifies the structure of LPS.
  2. Mutates LPS biosynthesis genes
  3. Reduces porins
• What antibiotic treats MDR A. Beaumannii?

  Tetracycline therapy —> Ampicillin + sulbactam + carbapenem.
• How does sulbactam work?

  1. B lactamase inhibition (The enzymes that break down antibiotics)