Abnormal proliferation and then degeneration of the trophoblastic villi
Types of gestational trophoblastic disease
Complete mole
Partial mole
Premature cervical dilatation
Cervix that dilate prematurely, cannot hold a fetus until term
Placenta previa
Placenta is implanted abnormally in the uterus, most common cause of painless bleeding in the third trimester of pregnancy
Degrees of placenta previa
Low lying
Marginal
Partial
Total placenta previa
Premature separation of the placenta (abruptio placenta)
Placenta appears to be implanted correctly but begins to separate and bleeding results
Predisposing factors for abruptio placenta
High parity
Advanced maternal age
Short umbilical cord
Chronic hypertensive disease
Pregnancy induced hypertension
Direct trauma
Vasoconstriction
Autoimmune antibodies
Chorioamnionitis
Predisposing factors for cause unknown placental abruption
High parity
Advanced maternal age
Short umbilical cord
Chronic hypertensive disease
Pregnancy induced hypertension
Direct trauma
Vasoconstriction
Autoimmune antibodies
Chorioamnionitis
Assessment of placental abruption
Sharp stabbing pain high in the uterine fundus
If labor begins, each contraction will be accompanied by pain over and above the pain of contraction
Heavy bleeding – evident if separation occurs at the edges
Couvelaire uterus (uteroplacental apoplexy) – hard board like uterus with no apparent or minimally apparent bleeding
Disseminated Intravascular Coagulation (DIC) may occur
Therapeutic management of placental abruption
1. Emergency situation
2. Large gauge IV catheter
3. Oxygen by mask
4. FHT and maternal VS monitoring
5. Lateral position
6. No abdominal, pelvic or vaginal examination
7. Unless separation is minimal, pregnancy must be TERMINATED
Disseminated Intravascular Coagulation (DIC)
Acquired disorder of blood clotting, fibrinogen level falls to below effective limits
Conditions associated with DIC development
Premature separation of placenta
PIH
Amniotic fluid embolism
Placental retention
Septic abortion
Retention of dead fetus
DIC
Extreme bleeding causes many platelets and fibrin from the general circulation rush to the site, not enough are left for the rest of the body
Tests for DIC
Test tube – clot must form
Platelet assessment – less than or equal to 100,000/uL
Prothrombin – low
Thrombin – elevated
Fibrinogen – less than 150 mg/dL
Management of DIC
1. Halt the underlying insult
2. IV administration of Heparin
3. Blood or platelet transfusion
Preterm labor
Labor that occurs before the end of the 37 weeks of gestation
Preterm labor
Persistent uterine contractions, cervical effacement over 80% and dilation over 1cm
Unknown cause
Conditions associated with preterm labor
Dehydration
UTI
Periodontal disease
Chorioamnionitis
Inadequate prenatal care
Assessment of preterm labor
Persistent, dull, low backache
Vaginal spotting
Pelvic pressure or abdominal tightening
Menstrual like cramping
Fetal fibronectin
Protein produced by trophoblast cells, presence indicates preterm contractions are ready to occur, absence indicates labor will not occur at least 14 days
Therapeutic management of preterm labor
1. Woman usually admitted
2. Bed rest
3. IV fluids – hydration may stop contractions
4. Tocolytic agent – halt labor (terbutaline)
5. Advise to limit strenuous activities
6. Fetal assessment – count to 10 test
Administration of terbutaline
1. Mixed with lactated Ringer's (not given purely)
2. Piggy back
3. Microdrip
4. Check blood pressure and pulse rate
5. If contractions are halt, oral terbutaline may be given
Drug administration in preterm labor
1. Steroid (betamethasone) – to hasten lung maturity
2. Effects after 24 hours and lasts 7 days
Preterm labor that cannot be halted
Membranes have ruptured
Cervix more than 50% effaced and 3-4 cm dilated
If fetus is very immature – CS
Method of delivery for preterm labor
1. If very immature – CS delivery to reduce pressure on the fetal head
2. Cord is clamped immediately – extra amount of blood could overburden the circulatory system