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Rat model of chronic IHF
1.
2-h
coronary occlusion followed by
reperfusion
2. 4 weeks later, rats injected intramyocardially with
TNNT2-4Fpolycistronic-NIL
or
LacZ-NIL
3.
4
months post-viral injection, outcomes assessed
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TNNT2-4Fpolycistronic-NIL gene therapy
Induces CM cell cycle
re-entry
Improves
LV
function
Effects sustained for at least
4
months
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TNNT2-4Fpolycistronic-NIL gene therapy induces CM
cell cycle re-entry
in chronic IHF and improves
LV function
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No reversal of
dilatation
or
adverse remodeling
observed
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Transient gene expression targeted to CMs
Crucial for
therapeutic benefits
in
chronic heart failure
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Improved
LV
function post-treatment with
TNNT2-4Fpolycistronic-NIL
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Scar size and healthy area measured using
Masson's trichrome
staining
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Immunohistochemistry used to assess heart tissue
post-treatment
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Heart failure
(HF) is a prevalent syndrome with high morbidity and mortality rates affecting
millions
worldwide
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Ischaemic heart failure
(
IHF
) is the most common form, resulting from myocardial ischaemia and CM death, leading to adverse structural changes and functional decline
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Chronic IHF remains
challenging
due to limited CM
regeneration capacity
, often leading to fibrous tissue replacement and progressive dilatation
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Further
research is needed to elucidate the mechanisms and optimize gene therapy strategies for long-term management of heart failure
View source
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