Inheritance of certain characteristics in a population, over multiple generations, could lead to a change in the whole species. Or sometimes the development of an entirely new species
We still do not know how life first developed, because many early life forms were soft bodied, so they decayed really quickly, making fossil remains really unlikely
Fossils formed could have also been destroyed, due to volcanic activity, earthquakes and more larger geological activity like the movement of tectonic plates.
You would still be infected. You can then pass these bacteria onto other people, and if they go to the doctor and receive the same antibiotic, it won't work on them either.