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Paper 1
Biol 115
HSA
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Created by
Pierre Gasly
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Cards (29)
What are the 2 main functions of Human Serum Albumin.
Transport
of
small
and
hydrophobic
molecules
Osmotic swelling
pressure
of blood plasma
Where is Human Serum Albumin produced.
Liver.
How many domains does Human serum albumin have.
3.
Which AA forms the disulphide bonds.
Cysteine
How are the domains split up.
LSL
double
loops.
How are alpha helixes packed.
Pairwise
with
hydrophobic
residues
on the
inside.
What molecules does human serum albumin transport.
Ions
Fatty
Acids
Hormo
nes
Drugs
Carboxylic
acids
How is hormone release affected when combined with HSA.
Slower.
Which part of HSA is responsible for Cu 2+ and Ni 2+ transport.
N-terminal.
Which molecules do the cystesine residues transport.
Cadm
ium
Gold
Silver
Mercury
What happens upon FA binding.
Co
nfor
mational ch
ange
FA
in
hydrophobic
residues
Is serum albumin present in plasma
Yes
What does a forest plot do
Allows
you to
compare
the
effects
of a
drug
across
different
studies. Each study is plotted and the
odds
ratio
calculated.
What is OR in a forest plot
This is the odds
ratio.
It
compares
the
individual
study
to a
control
to see which is better.
What does OR = 1 in a forest plot mean
That the drug has
no
effect compared to the
control
What does OR > 1 mean in a forest plot
The
test
produced
better
results than the
control
What does OR < 1 mean in a forest plot
The
control
produces
better results
than the
test
What is the diamond in a forest plot
It is the
combined data
of all the studies shown.
What type of plot is this
A
forest
plot
What is the Mr of HSA
66,500
What is the PI
It is the
isoelectric point.
What is the isoelectric point of HSA
5.67
What is the isoelectric point
The pH at which the molecule has
no
net charge because it is
dipolar.
What type of FA does HSA transport
long chain
What type of carboxylic acids does albumin transport
Heterocyclic
and
aromatic
What is a
heterocyclic
molecule
A molecule which has an element other than carbon and
hydrogen
in the
aromatic ring
Which cysteine residue is involved in transport for HSA
34
How many alpha helixes surround the FA in HSA
3
or
4
What type of protein is HSA
Globular