HSA

Cards (29)

  • What are the 2 main functions of Human Serum Albumin.
    1. Transport of small and hydrophobic molecules
    2. Osmotic swelling pressure of blood plasma
  • Where is Human Serum Albumin produced.
    Liver.
  • How many domains does Human serum albumin have.
    3.
  • Which AA forms the disulphide bonds.
    Cysteine
  • How are the domains split up.
    LSL double loops.
  • How are alpha helixes packed.
    Pairwise with hydrophobic residues on the inside.
  • What molecules does human serum albumin transport.

    1. Ions
    2. Fatty Acids
    3. Hormones
    4. Drugs
    5. Carboxylic acids
  • How is hormone release affected when combined with HSA.
    Slower.
  • Which part of HSA is responsible for Cu 2+ and Ni 2+ transport.
    N-terminal.
  • Which molecules do the cystesine residues transport.

    1. Cadmium
    2. Gold
    3. Silver
    4. Mercury
  • What happens upon FA binding.

    1. Conformational change
    2. FA in hydrophobic residues
  • Is serum albumin present in plasma
    Yes
  • What does a forest plot do
    Allows you to compare the effects of a drug across different studies. Each study is plotted and the odds ratio calculated.
  • What is OR in a forest plot
    This is the odds ratio. It compares the individual study to a control to see which is better.
  • What does OR = 1 in a forest plot mean
    That the drug has no effect compared to the control
  • What does OR > 1 mean in a forest plot
    The test produced better results than the control
  • What does OR < 1 mean in a forest plot
    The control produces better results than the test
  • What is the diamond in a forest plot
    It is the combined data of all the studies shown.
  • What type of plot is this
    A forest plot
  • What is the Mr of HSA
    66,500
  • What is the PI
    It is the isoelectric point.
  • What is the isoelectric point of HSA
    5.67
  • What is the isoelectric point
    The pH at which the molecule has no net charge because it is dipolar.
  • What type of FA does HSA transport
    long chain
  • What type of carboxylic acids does albumin transport
    Heterocyclic and aromatic
  • What is a heterocyclic molecule

    A molecule which has an element other than carbon and hydrogen in the aromatic ring
  • Which cysteine residue is involved in transport for HSA
    34
  • How many alpha helixes surround the FA in HSA
    3 or 4
  • What type of protein is HSA
    Globular