Quiz 7 & 8

• A drug that reduces the activity of a given receptor by binding to the standard binding pocket for ligands and displacing the endogenous ligand for that receptor would be considered a competitive antagonist.
• Nicotine is an agonist of acetylcholine.
• Caffeine is an adenosine receptor antagonist, causes an increase in catecholamine levels, and reduces feelings of sleepiness, but NOT possible to develop an addiction.
• A drug can affect a neural system in all neurotransmitter receptors, reuptake systems, and degradation/recycling systems sites/processes.
• Caffeine, amphetamine, and cocaine drugs are stimulants.
• The psychiatric disease marked by a combination of positive symptoms like hallucinations, and negative symptoms like slowed cognition and emotional withdrawal is called schizophrenia.
• Neuroleptic drugs used to treat schizophrenia typically act at dopamine receptor 2 (D2).
• In schizophrenia, the disruption in memory loss may be linked to disruption of cellular organization in the hippocampus.
• An SSRI like Prozac or Zoloft work to ease depression symptoms by preventing the reuptake of serotonin.
• ECT or deep brain stimulation is shown to be more effective than drugs at treating difficult cases of depression
• The disorder of memory formation that is common in alcoholics, and tied to disruption of the mammilary bodies is called Korsakoff Syndrome.
• Memory formation and Long-term Memory Recall/Storage are NOT both dependent on the hippocampus.
• The NMDA receptor is typically blocked by magnesium.
• When your brain stores information about a motor skill, it is considered a non-declarative memory.
• Signs of increased synaptic strength/connectivity between neurons include an increased dendritic branching, increases number of dendritic spines, and heightened electrical activity at synapses.
• To facilitate LTP, multiple glutamate receptors become activated, which the AMPA is activated first.
• Human memory is not almost always factually correct, is subject to bias, and is easier to manipulate after initial formation.
• Particular episodic memories are stored in the parts of the cortex associated with their initial processing.