As the initial surge of adrenaline subsides, the hypothalamus activates a stress response system called the HPA axis. The hypothalamus (H). In response to the continued threat, it releases a chemical messenger CRH which is released into the bloodstream. The pituitary gland (P). When CRH reaches this gland, it causes the glad to produce and release ACTH which is transported through the blood stream to the target of the adrenal glands. Adrenal glands (A). This stimulates the release of various stress-related hormones including cortisol