Alternative drugs include SNRI's (Serotonin-Noradrenaline Reuptake Inhibitors), which work in a similar way to SSRIs, but as well as increasing levels of serotonin, they also increase another neurotransmitter called noradrenaline. And Tricyclics which are reserved for those that SSRIs do not work for: It is an older antidepressant and has more severe side effects than SSRIs, so is usually only used on those that other drug therapies have not worked.