1 = irritation of trachea and bronchi
2 = reduced lung function and increased breathlessness caused by swelling and narrowing of lungs airways
3 = damage to the cells lining the airways from cigarette smoke, leading to a build-up of excess mucus in the lungs - leads to smokers cough in an attempt to get rid of mucus
4 = reduction in efficiency of gaseous exchange - increase risk of COPD (chronic obstructive pulmonary disease)