> Hyperdopaminergia in the subcortex - high dopamine activity in central areas in the brain such as Brocas area may be associated with auditory hallucinations
> Hypodoperminergia in the cortex - Low dopamine activity in the prefrontal cortex have been associated with the negative symptoms of schizophrenia such as avolition
> It has been suggested that cortical hypodopaminergia leads to subcortical hyperdopaminergia. Both high and low levels of dopamine in different brain regions are involved in different symptoms of schizophrenia
