1. Action potential travels down the axon of the presynaptic neuron
2. Vesicles containing neurotransmitters merge with the cell membrane and release neurotransmitters into the synaptic cleft
3. Receptors on the postsynaptic neuron's dendrite membrane detect neurotransmitters, changing the chemistry of the postsynaptic neuron
4. If the change passes a threshold, a new action potential is triggered and the message is passed on
5. Neurotransmitters detach from receptors and return to the presynaptic cell via transport proteins (reuptake)