1. May result in spontaneous abortion
2. Birth result in spontaneous abortion one or multiple birth anomalies such as: Cleft palate, talipes and eruption of teeth
3. Cardiac defects (patent ductus arteriosus, atrial septal defect)
4. Eye defects (glaucoma, retinopathy, micropthalmia)
5. Neurologic (Microcephaly, mental retardation, psychomotor retardation, vasomotor instability)