Earliest case of man-made extinction occurred over 12,000 years ago, brought upon by hunting and territorial disputes. The Holocene extinction, also called the Sixth Extinction or more aptly Anthropocene Extinction, occurred from as early as between 100,000 to 200,000 years up to the present. Ongoing extinction of several species – both flora and fauna – due to human activity. Growing population necessitated finding additional resources, leading to overhunting and overfishing common prey. Albeit waging wars 5,000 years ago with other tribes seemed to be the early solution, they were able to find out some that engaging in a peaceful negotiation was also a possible and less bloody method. They could get hold of things not present in their towns by offering something of same value present in theirs. Trade emerged, leading to cross-town and eventually cross-cultural interaction as more products were exchanged and the initial needs extended to wants. They perceived that those who have many, live comfortably and thus are generally happier than those who do not have sufficient wealth. They began to hunt, farm, and produce thing with prospect of profit. Products of every kind were exchanged, ranging from necessary ones such as crops, cattle, poultry, others of kind, and clothing materials, up to metals, accessories, weapons, spices, literature, and entertainment. When they could not sell products, they used their skills and got compensated for it – bringing forth a specialized group of artisans. Humanity became more complex. The primary was not merely to survive, but to live the good life. Technology has been instrumental in searching for the good life because people were able to come up with creations that would make life easier, more comfortable, and more enriching. Medicine was born, although it would take a considerably long time before it part ways with potion.