Immune System

• which drugs are used for cancer?

  nitrogen mustards

  anthracyclines

  vinca alkaloid

  gonadotropin-releasing hormones

  estrogen receptor blockers

  interferon alfa-2B
• adverse effects of cancer drugs

  fatigue, hair loss, kidney problems, mood or weight changes, increased risk of bleeding or bruising, infection, anemia, dry skin, brain fog, bone marrow suppression, hepatotoxicity
• which drugs are used for HIV?

  NRTIs - zidovudine

  entry/infusion inhibitor - enfuvirtide

  CCR5 antagonist - maraviroc

  NNRTIs - nevirapine

  integrase inhibitor - raltegravir

  protease inhibitor - fosamprenavir
• adverse effects of zidovudine

  bone marrow suppression (anemia, neutropenia), GI effects, CNS effects, fever, myalgia
• key monitoring parameters of zidovudine

  CBC, liver and renal function, I&O, electrolytes, CD4 count, HIV viral load
• patient education for zidovudine

  report onset of infection, fever, myalgia, no new OTC or prescribed drugs
• adverse effects of enfuvirtide

  injection site reaction, pneumonia (cough, SOB, fever), allergic reaction (elevated liver enzymes)
• key monitoring parameters of enfuvirtide

  injection site (SQ), pneumonia s/s, I&O, electrolytes, CBC, liver and renal function, CD4 count, HIV viral load
• patient education for enfuvirtide

  rotate injection sites
• adverse effects of maraviroc

  CNS effects, musculoskeletal pain, cough, upper respiratory infection, liver damage
• key monitoring parameters of maraviroc

  CNS symptoms, liver and renal function, CBC, CD4 counts, HIV viral load
• patient education for maraviroc

  take with or without food, report musculoskeletal s/s, no other OTC or prescription drugs
• adverse effects of nevirapine

  rash (Stevens Johnson syndrome or erythema multiforme), GI effects, increased liver enzymes
• key monitoring parameters of nevirapine

  rash, liver and renal function, I&O, CBC, CD4 count, HIV viral load, electrolytes
• patient education for nevirapine

  no antacids, may dissolve tablet in water, no new OTC or prescription drugs
• adverse effects of raltegravir

  GI and CNS effects
• key monitoring parameters of raltegravir

  GI and CNS effects
• patient education for raltegravir

  take with or without food, take analgesic for headache if necessary
• adverse effects of fosamprenavir

  hyperglycemia, diabetes mellitus, fat redistribution, increased blood lipids, decreased bone density, liver toxicity, GI effects
• key monitoring parameters of fosamprenavir

  blood glucose, fat distribution, lipids, bone density, liver enzymes
• patient education for fosamprenavir

  report increased thirst, take with food, increase exercise, calcium, and vitamin D intake, no other OTC or prescription drugs