pKa(equation, relationship between pKa/Ka and acid strength, relation to pH)
-log(ka).The smaller the pKa, the stronger the acidThe smaller the Ka, the weaker the acidThe pH at which 50% of the species are ionised.After +/- 2 units away from pKa, the acid/base will be fully ionised/unionised
Henderson-Hasselbalch equation(What is it? What does it show? What does it allow us to calculate? How does it rearrange?)
pH = pKa + log [conj. base]/[conj. acid]]Shows the relationship between pH and pKa. Allows us to calculate ratio of ionised to unionised drug at any pH[base]/[acid] = 10^(pH-pKa)