lectures 12-15

• Kidd

  Reacts with polyspecific AHG
• Duffy antibodies


  Anti-Fya is common, anti-Fyb is 20x less common
• KEL antigens

  • Also on myeloid progenitor cells, testis, lymphoid tissues, and with the Xk protein in skeletal muscle
• Kell antibodies HDFN

  Different from anti-D in that there is lower hemolysis, no hyperbilirubinemia, low reticulocyte count, profound anemia and erythroblastosis, anti-K suppresses erythropoiesis
• Anti-LWab

  Reacts with all cells except the rare Lwnull and Rhnull red cells
• Sciana

  7 antigens; rarely seen HTR, mild to severe HDFN
• Chido-Rogers

  Not destroyed by enzymes; antibodies do not cause HDFN or HTr
• Gerbich

  11 antigens - 6 are high prevalence, and 5 are low prevalence
• Kell


  • K/k
  • Jsa/Jsb
  • K11/K17
  • K14/K24
  • VLAN/VONG
• Warm autoantibodies

  Warm autoimmune hemolytic anemia, systematic lupus erythematosus, multiple myeloma, CLL, lymphoma
• Rh immune globulin (RhIG, RhoGAM) and intravenous immunoglobulin (IVIG)


  Antenatal and postnatal patients
• Intravenous RhIG


  Combo of anti-D and other antibodies for immune-thrombocytopenia
• Reagent cells licensed by the FDA

  • D
  • C
  • c
  • E
  • e
  • M
  • N
  • S
  • s
  • Jka
  • Jkb
  • Lea
  • Leb
  • P1
  • K
  • k
  • Fya
  • Fyb