The cardiovascular system can be compared to a muscular pump equipped with one-way valves and a system of large and small plumbing tubes within which the blood travels
Approximately the size of a person's fist, the hollow, cone-shaped heart weighs less than a pound
Snugly enclosed within the inferior mediastinum, the medial cavity of the thorax, the heart is flanked on each side by the lungs
Its more pointed apex is directed toward the left hip and rests on the diaphragm, approximately at the level of the fifth intercostal space
Its broad posterior superior aspect, or base, from which the great vessels of the body emerge, points toward the right shoulder and lies beneath the second rib
The heart is enclosed in a double-walled sac called the pericardium and is the outermost layer of the heart
The loosely fitting superficial part of this sac is referred to as the fibrous pericardium, which helps protect the heart and anchors it to surrounding structures such as the diaphragm and sternum
Deep to the fibrous pericardium is the slippery, two-layer serous pericardium, where its parietal layer lines the interior of the fibrous pericardium
Pericarditis can cause chest pain that is sharp and stabbing (caused by the heart rubbing against the pericardium), may get worse when you cough, swallow, take deep breaths or lie flat, and feels better when you sit up and lean forward
1. When there is a fluid build-up in the space between the pericardium, it can cause a condition called pericardial effusion
2. If the fluid builds up quickly, it can cause cardiac tamponade, a sudden build-up of fluid in between the layers of the pericardium that keeps your heart from working like it should and can cause your blood pressure to drop
Some autoimmune diseases, such as lupus, rheumatoid arthritis and scleroderma can cause pericarditis. Other causes of pericarditis include injury to the chest, such as after a car accident, other health problems such as kidney failure, tumors, genetic diseases such as Familial Mediterranean Fever, or rarely, medications that suppress the immune system
The septum that divides the heart longitudinally is referred to as either the interventricular septum or the interatrial septum, depending on which chamber it separates
Heart valves are simple devices, and the heart—like any mechanical pump—can function with "leaky" valves as long as the damage is not too great. However, severely deformed valves can seriously hamper cardiac function
The valve cusps become stiff, often because of repeated bacterial infection of the endocardium (endocarditis), forcing the heart to contract more vigorously than normal to create enough pressure to drive blood through the narrowed valve