Amoxicillin

• What is amoxicillin?

  Penicillin deriviative
• What is the pharmacology of amoxicillin?

  Target: Penicillin-binding proteins (PBPs)

  Activity: Antagonist
• MOA - Amoxicillin

  Binds to & inhibits PBPs → no crosslinking of D-alanine & D-alanine → unable to build & repair cell wall → bacteria upregulate autolytic enzymes → bactericidal action
• What are the indications of amoxicillin?

  Bacterial infections

  Broad spectrum
• What are the side effects of amoxicillin?

  Diarrhoea

  Nausea

  Skin reactions