1st Line-Lifestyle Advice, increase fibre, fruit, fluids & exercise 30-60mins on min 5 days per week
2nd Line Bulkforming laxatives (e.g. ispaghula,methylcellulose, sterculia-swell up in the gut to increase faecal mass which stimulates peristalsis. Onset within 24hrs, full effect in 2-3 days. Safe in pregnancy)
3rd Line-Osmotic laxatives (e.g. lactulose,macrogol-takes2-3 days to work. Side effects: flatulence,cramps, abdominal discomfort on initiation)
4th Line-Stimulant laxatives (e.g. senna, bisacodyl, sodiumpicosulfate,glycerol suppository)-work by directly stimulating peristalsis through increasing release of water & electrolytes by the intestinal mucosa. Onset within 6-12 hrs (overnight. Suppositories are immediate. Senna can colour the urine red/brown). Avoid stimulant laxatives in pregnancy