The hypothalamus reacts to raise the set point and the body responds by producing and conserving heat. Several hours pass before the body temperature reaches the new set point
Differ depending on the causative pyrogen. The increase or decrease in the pyrogen activity results in fever spikes and declines at different times of the day. The duration and degree of fever depend on the strength of the pyrogen and the ability of the individual to respond
Vital signs during heatstroke include body temperature sometimes as high as 45°C (113°F), with an increase in heart rate (HR) and lowering of BP. Hot, dry skin is the most important sign