HPO Feedback Loop (Continuation)
4. The theca interna, a layer within the Graafian follicle, produces androgens. These androgens diffuse into the surrounding granulosa cells of the follicle.
5. Granulosa cells convert the androgens, with the help of an enzyme called aromatase, into estrogen. Estradiolis the main type of estrogen produced.
6. Rising estrogen levels from the Graafian follicle trigger a surge in LH release from the pituitary gland.