Levonorgestrel and ulipristal (a progesterone receptor modulator)
Levonorgestrel mode of action
The mode of action is not fully understood; it acts both to stop ovulation and inhibit implantation
Timing and Efficacy of Levonorgestrel
It should be taken as soon as possible because its efficacy decreases with time; it must be taken within 72 hours of unprotected sexual intercourse (UPSI)
Levonorgestrel Dosage
A single dose of 1.5 mg
Levonorgestrel Dose Adjustment
For individuals with a BMI >26 or weight over 70 kg, the dose should be doubled
Efficacy of Levonorgestrel
It is 84% effective if used within 72 hours of UPSI
Side Effects of Levonorgestrel
Disturbance of the menstrual cycle and vomiting in around 1% of users
Vomiting and Levonorgestrel
The dose should be repeated if vomiting occurs within 3 hours of taking levonorgestrel
Repeat Use of Levonorgestrel
Yes, if clinically indicated
Starting Hormonal Contraception After Levonorgestrel
Hormonal contraception can be started immediately after using levonorgestrel (Levonelle) for emergency contraception
Ulipristal Mode of Action
Inhibition of ovulation
Ulipristal Dosage and Timing
A 30 mg oral dose taken as soon as possible, no later than 120 hours after intercourse
Ulipristal and Levonorgestrel
Concomitant use is not recommended
Ulipristal and Hormonal Contraception
Ulipristal may reduce the effectiveness of hormonal contraception; contraception with the pill, patch, or ring should be started or restarted 5 days after taking ulipristal, using barrier methods during this period
Ulipristal and Asthma
Caution should be exercised in patients with severe asthma
Repeated Dosing of Ulipristal
Yes, repeated dosing within the same menstrual cycle is now allowed
Breastfeeding and Ulipristal
Breastfeeding should be delayed for one week after taking ulipristal
Copper IUD Effectiveness
It is the most effective method, being 99% effective
Timing for Copper IUD Insertion
Within 5 days of UPSI, or up to 5 days after the likely ovulation date if the woman presents later
Mechanism of Copper IUD
It may inhibit fertilization or implantation
Antibiotics and Copper IUD
Prophylactic antibiotics may be given if the patient is considered to be at high risk of sexually transmitted infection
Long-term Use of Copper IUD
Yes, it can be left in place for long-term contraception, or at least until the next period if the client wishes for its removal
Choosing Between IUD and Oral Contraception
If a copper IUD is not acceptable or suitable, oral emergency contraception should be considered