most common genotype in white is R1r; most common genotype for black is R0r
Warm autoantibodies often appear to have “anti-e-like specificity”
Rh-mediated hemolytic transfusion reactions usually result in extravascular hemolysis
D Deletion - individuals do not posses the genes needed to synthesize Cc or Ee
Rh null phenotype- individuals lack all Rh antigens on their RBCs; individuals with Rh null phenotype demonstrate mild compensated
LW antigen was demonstrated as an antigen present on Thesus monkey and on majority of human RBCs.
Genetic weak D- D antigen expressed is complete but few in number
C-Trans- also known as position effect or gene interaction effect; D allele is in trans (or opposite side) to the allele carrying C
Partial D(D mosaic)- occurs when the D epitopes within the D antigen is either missing or altered.
Weak D testing is a form of Indirect Antiglobulin Test
AHG also known as COOMB‘s Reagent; they are antibodies that target the human globulin . • serves as a bridge to connect two-non agglutinating antibodies.
DIRECT ANTIGLOBULIN TEST • detects for In vivo sensitization or coating. • specimen is RBCs