RH BLOOD GROUP SYSTEM

Cards (25)

  • Rh genes and RHCE gene found in chromosomes 1
  • Rh1= D
  • Rh 2= C
  • Rh3= E
  • Rh4 = c
  • Rh5 = e
  • most common genotype in white is R1r; most common genotype for black is R0r
  • Warm autoantibodies often appear to have “anti-e-like specificity”
  • Rh-mediated hemolytic transfusion reactions usually result in extravascular hemolysis
  • D Deletion - individuals do not posses the genes needed to synthesize Cc or Ee
  • Rh null phenotype- individuals lack all Rh antigens on their RBCs; individuals with Rh null phenotype demonstrate mild compensated
  • LW antigen was demonstrated as an antigen present on Thesus monkey and on majority of human RBCs.
  • Genetic weak D- D antigen expressed is complete but few in number
  • C-Trans- also known as position effect or gene interaction effect; D allele is in trans (or opposite side) to the allele carrying C
  • Partial D(D mosaic)- occurs when the D epitopes within the D antigen is either missing or altered.
  • Weak D testing is a form of Indirect Antiglobulin Test
  • AHG also known as COOMB‘s Reagent; they are antibodies that target the human globulin . • serves as a bridge to connect two-non agglutinating antibodies.
  • DIRECT ANTIGLOBULIN TEST • detects for In vivo sensitization or coating. • specimen is RBCs
  • Hemolytic Transfusion Reaction- recipient antibody coating RBCs
  • Hemolytic Disease of the Newborn- maternal antibody coating fetal RBCs
  • Autoimmune Hemolytic Anemia- autoantibody coating RBCs
  • INDIRECT ANTIGLOBULIN TEST • detects for in vitro sensitization or coating • specimen Serum
  • crossmatching= detects recipient antibody reacting with donor cells
  • antibody screening= detects antibody reacting with screening cells
  • antibody panel= detects antibody reacting with panel cells.