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    • Scrotum
      An outpouching of the lower part of the anterior abdominal wall that contains the testis, epididymides, and lower end of the spermatic cord
    • Structure of the spermatic cord

      • Vas deferens
      • Testicular artery
      • Testicular veins (pampiniform plexus)
      • Testicular lymph vessels
      • Autonomic nerves
      • Processus vaginalis
      • Cremasteric artery
      • Artery of the vas deferens
      • Genital branch of the genitofemoral nerve
    • Types of scrotal swellings

      • Cystic
      • Solid
      • Neither tumor (benign/malignant)
      • Varicocele
      • Hernia
      • Hydrocele
      • Epididymal cyst/spermatocele
      • Haematocele
    • Characteristics of scrotal swellings

      • Painful
      • Painless
    • Causes of painful scrotal swellings

      • Epididymitis/epididymorchitis
      • Hydrocele
      • Torsion of spermatic cord
      • Inguinoscrotal (total) hernia
      • Torsion of testicular appendages
      • Epididymal cysts/spermatocele
      • Haematocele
      • Varicocele
      • Incarcerated inguinoscrotal hernia
      • Testicular tumors
    • Testicular tumors account for 10% of scrotal swellings
    • Hydrocele
      A collection of abnormal quantity of serous fluid in the tunica vaginalis. If it contains pus or blood it is called pyocele or haematocele respectively.
    • Congenital communicating hydrocele

      Incomplete obliteration of the processus vaginalis allowing fluid collection within tunica vaginalis
    • Hernia
      A large opening of the processus vaginalis which may allow abdominal contents to enter the scrotal sac
    • Causes of hydrocele

      • Primary (cause unknown, associated with patency of processus vaginalis)
      • Secondary (fluid accumulation secondary to pathology inside the testis like epididymo-orchitis, testicular tumor, and trauma)
    • Symptoms of hydrocele

      • Painless swelling
      • Embarrassment
      • Frequent and painful micturition (if secondary to epididymo-orchitis)
    • Hydrocele does not affect fertility
    • Examination findings in hydrocele

      • Unilateral or bilateral swelling
      • Normal colour and temperature
      • Tender (if secondary)
      • Fluctuant with fluid thrill
      • Not reducible
      • Testis impalpable and transilluminate
    • Management of hydrocele

      • In children: most neonatal hydroceles resolve in first 2 years, persistent ones treated with herniotomy
      • In adults: surgical (subtotal excision, Jabouley's operation, Lord's operation, Chinese operation)
      • Secondary hydrocele: treat underlying condition
    • Epididymal cyst

      Cystic degeneration of the epididymis, filled with crystal-clear fluid, found in middle age, better to leave it as excision may cause obstruction
    • Spermatocele
      A unilocular retention cyst derived from some portion of the sperm-conducting mechanism of the epididymis, typically lies in the epididymal head, contains spermatozoa, small ones can be ignored, larger ones can be aspirated or excised
    • A child or adolescent with acute scrotal pain, tenderness, or swelling should be looked on as an emergency situation requiring prompt evaluation, differential diagnosis, and potentially immediate surgical exploration
    • Causes of painful scrotal swellings

      • Testicular torsion
      • Epididymo-orchitis
    • Testicular torsion

      The most urgent problem, high risk of loss due to infarction (90%), may have torsion of cord or appendages, more common in undescended testes due to absence of fixation
    • Types of testicular torsion

      • Extravaginal (exclusive to perinatal)
      • Intravaginal (90% of adolescent age group)
    • History and physical exam findings in testicular torsion

      • Sudden onset of pain
      • Past history of similar pain in 50%
      • Cremasteric reflex may be absent
      • Prehn's sign: Elevation of testes does not relieve pain
      • Angel sign: Transverse or oblique testicular lie
    • Diagnosis and management of testicular torsion

      • If certain, emergent surgery
      • If uncertain, nuclear scan or ultrasonography to document blood flow
      • < 6 hours, 90% salvage, detorsion and orchiopexy bilaterally
      • > 24 hours, 100% loss and atrophy, orchidectomy
      • Attempt manual detorsion - outward, "open the book"
    • Torsion of testicular appendages

      Rarely seen after puberty, presents with pain, may develop scrotal swelling & erythema, "blue dot sign" seen early, treat symptomatically
    • Epididymitis
      Most common acute scrotum post-pubertal, gradual onset of pain, fever in 40%, dysuria in 50%, urinalysis may show pyuria in 50%
    • Epididymo-orchitis
      Inflammation confined to the epididymis is epididymitis, infection spreading to the testis is epididymo-orchitis, the most common cause of acute scrotum
    • Modes of infection in epididymo-orchitis

      • Infection reaches the epididymis via the vas from a primary infection of the urethra, prostate or seminal vesicles
      • Blood-borne infections of the epididymis are less common
    • Clinical features of epididymo-orchitis
      • Initial symptoms are those of urinary tract infection
      • The epididymis and testis swell and become painful
      • Fever
      • The scrotal wall, at first red, oedematous and shiny, may become adherent to the epididymis
      • Resolution may take 6–8 weeks to complete
      • Occasionally, an abscess may form and discharge of pus through the scrotal skin
    • Acute epididymo-orchitis develops in about 18% of males suffering from mumps
    • The main complication of epididymo-orchitis is testicular atrophy, which may cause infertility if the condition is bilateral
    • Investigations for epididymo-orchitis
      • GUE: pyuria
      • Urine C&S: positive
      • WBC count: leukocytosis
      • Scrotal ultrasound + Doppler: hyperperfusion
    • Differentiating features between testicular torsion and epididymo-orchitis
      • Teenagers vs adulthood
      • Sudden onset vs gradual onset
      • No fever vs fever present
      • High testis level vs normal
      • Abnormal lie vs normal
      • Scrotal elevation increases pain vs pain decreased
      • Normal urine exam vs GUE show pus cells
      • Duplex US: avascular vs hypervascular
      • Cremasteric reflex absent vs present
    • Epididymitis management

      Confirm that torsion of testis does not exist, treat with scrotal elevation, antibiotics (keflex, septra), refer for persistence of pain/swelling
    • Treatment of epididymo-orchitis
      • Broad spectrum antibiotics for 2 weeks (3rd generation cephalosporin or quinolones)
      • Scrotal support
      • Supportive therapy (analgesics, antipyretics, anti emetics, IVF)
      • If suppuration occurs (abscess): drainage is necessary
    • Testicular injuries

      Blunt or penetrating trauma can cause contusion and rupture of the testis, associated with a collection of blood around the testis, ultrasound is the investigation of choice, haematocele should be drained and the tunica albuginea repaired, severely damaged testis may have to be removed
    • Cryptorchidism
      Almost 1% of all full-term male infants are affected at the age of one year, categorisation into palpable and non-palpable testis is most appropriate
    • Complications of cryptorchidism
      • Cancer (25-30 times increased risk, not affected by orchiopexy)
      • Infertility (50% abnormal semen in unilateral, 70% in bilateral)
      • Testicular torsion
      • Trauma
      • Hernia
    • Assessment of cryptorchidism

      • Physical examination is the only method to differentiate palpable or non-palpable testes
      • Radiological imaging is only 44% accurate
      • Diagnostic laparoscopy is required to confirm intra-abdominal, inguinal and absent/vanishing testis
    • In cases of bilateral non-palpable testes and any suggestion of sexual differentiation problems, urgent endocrinological and genetic evaluation is mandatory
    • Treatment of cryptorchidism

      • Medical therapy using hCG or GnRH has a maximum success rate of 20%
      • Palpable testis: surgery includes orchidofuniculolysis and orchidopexy, with success rates of up to 92%
      • Non-palpable testis: inguinal surgical exploration with the possibility of orchidectomy
    • There is no reliable examination to confirm or rule out an intra-abdominal, inguinal and absent/vanishing testis (nonpalpable testis), except for diagnostic laparoscopy
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